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DeCS
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Descriptor English:
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Lambert-Eaton Myasthenic Syndrome
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Descriptor Spanish:
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Síndrome Miasténico de Lambert-Eaton
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Descriptor Portuguese:
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Síndrome Miastênica de Lambert-Eaton
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Synonyms English:
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Eaton-Lambert Syndrome
Myasthenic Syndrome, Lambert-Eaton
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Tree Number:
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C04.588.614.550.225
C04.730.856.225
C10.114.468
C10.574.781.500
C10.668.758.450
C20.111.258.350
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Definition English:
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An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) |
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History Note English:
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1990
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Allowable Qualifiers English:
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Record Number:
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24764
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Unique Identifier:
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D015624
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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